Pulmonary Disease Cystic Fibrosis: Review Questions Subramanyam Chittivelu, MD, FCCP Dr. Chittivelu is Assistant Professor, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, and Clerkship Director in Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, TX Choose the single best answer for each question.
	1. Each of the following statements regarding the genetics of cystic fibrosis (CF) is correct EXCEPT: The CF gene codes for a protein called cystic fibrosis transmembrane regulator (CFTR) CFTR is largely expressed in epithelial cells of the airways, the pancreas, the biliary system, the genitourinary system, and the sweat glands Although there are a few hundred mutations that exist for CF, the most prevalent mutation among northern Europeans is W1282X Severity of lung disease and liver disease cannot be predicted by genotype Click here to compare your answer. 2. Which of the following exocrine glandular ducts are NOT obstructed in cystic fibrosis? Pancreas Lungs Sweat glands Glands of the uterine cervix Click here to compare your answer. 3. Which of the following is NOT a pulmonary complication of CF? Massive hemoptysis and pneumothorax Atelectasis and acute respiratory failures Allergic bronchopulmonary aspergillosis and hypertrophic pulmonary osteoarthropathy Lymphangiomyomatosis and chylothorax Click here to compare your answer.		4. Which of following statements regarding the mechanism of action of recombinant human deoxyribonuclease (rhDNase) in CF is correct? rhDNase cleaves the extracellular DNA from the neutrophils in sputum to make it less viscous rhDNase’s potent antibacterial action prevents the growth of pseudomonads and staphylococci rhDNase has antibacterial, bronchodilator, and mucolytic actions rhDNase corrects the defect in the CF gene on chromosome 7 Click here to compare your answer. 5. Each of the following statements regarding pregnancy in women with CF is correct EXCEPT: Impairment of pulmonary function is the major predictor of both maternal and fetal outcome CF patients have an increased risk for premature delivery The maternal and fetal outcome is good for most cystic fibrosis patients The pregnancy need not be a planned one Click here to compare your answer.
Hospital Physician     JCOM     Seminars in Medical Practice Hospital Physician Board Review Manuals About TWC    Subscribe    Contact TWC    Home    Search   Site Map Copyright © 2008, Turner White Communications Updated 1/04/08 • kkj